Shopsin Lab Group

Bo Shopsin, MD, PhD, and members of his lab group. 

Bo Shopsin, MD, PhD
Assistant Professor, Departments of Medicine and Microbiology

522 First Avenue
Smilow Research Building
Room 1001, 10th Floor
New York, NY 10016
Office: 212-263-9039
Lab: 212-263-0458
Fax: 212-263-9180
Email: Bo Shopsin

Administrative Assistant: Maria Villamor
Office: 212-263-9085
Email: Maria Villamor

Key Words:

Staphyloocccus aureus; microbial pathogenesis, quorum sensing, colonization, transmission, mucosal immunity.

 

Biographic Details:

Medical Education: MD, NYU School of Medicine in 2001
Graduate Education: PhD in Microbiology in 2000, NYU School of Medicine
Postdoctoral Training:  2007-2009, NYU School of Medicine under Richard Novick 
Academic Responsibilities: 2012-Present, Assistant Professor of Medicine and Microbiology
Honors: 2010, Michael Saperstein Medical Scholar Research Award

 

Research Interests:

Our lab is focused on understanding the adaptive changes in S. aureus that take place during infection. An integrated approach is used that incorporates new technologies to detect low abundance variants in pooled bacterial populations, traditional bacterial and evolutionary genetics, andmolecular population genetic analysis. A special focus of these studies is on the identification of within-host variation in the agr locus, a global regulator of virulence in S. aureus. agr mutants are attenuated for virulence in animal models of infection, and the majority of clinical isolates have afunctional agr locus. However, agr-defective strains are frequently recovered from patients with a variety of hospital-acquired infections, suggesting that the occurrence of these strains may be favored under certain in vivo conditions. This work is motivated by practical questions in infectious diseases (such as the best use of antimicrobials that target agr and virulence), as well as more basic yet closely intertwined questions, such as how to explain the alterations that are responsible for adaptive changes at different stages of S. aureus infections.

 

Link to Publications 


People:

Postdocs:

Nirav Patel, PhD
(Nirav.Patel@nyumc.org)
Nirav Patel, PhD

Deena Altman, MD
(altman.deena@gmail.com
Deena Altman, MD

Graduate Student:

Ramya Gopal
(Ramya.Gopal@nyumc.org)
Ramya Gopal

Technician:

Hannah Rose
(Hannah.Rose@nyumc.org
Hanna Rose

Alumni:

Past Postdocs:

Name;  level Term Present or last known position
Simon Agolory, MD; Infectious Diseases Fellow 2008-2009 Lieutenant, Epidemic Intelligence Service, CDC, Atlanta, GA
Davida Smyth, PhD;  Postdoctoral Fellow 2010-present Asst. Prof, New York City College of Technology, Brooklyn, NY
Tiffany Otto, MD; Infectious Diseases Fellow 2010-2011 Weill Cornell, Pediatrics, New York, NY
Angelena Labella, MD; Infectious Diseases Fellow 2011-12 Instructor in Medicine, Columbia Presbyterian, New York, NY

Past Students:

Name;  level Term Present or last known position
Christian Eaton; Medical Student (Honors Thesis) 2008-2009 Residency, Virginia Mason Medical Center, Seattle, WA
Gregory Wasserman; Masters Student 2009-2011 Ph.D. candidate, Boston Univ., Boston, MA
Lili Velickovi; Medical Student (Honors Thesis) 2010-2011 Medical student, Karolinsa, Stockholm, Sweden

Contacting the lab (USPS and direct deliveries)
Smilow Research Bldg.
10th floor, Lab 1004
522 First Ave
New York, NY 10016

Maps

The Shopsin lab is located in the Smilow Research Building. View Google map.
Map of NYU Langone Medical Center/Tisch Hospital (in PDF format)