Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common, life-threatening single-gene disease. It affects over 500,000 individuals in the United States and 12 million worldwide. This disease is the fourth leading cause of kidney failure in the US.
ADPKD does not discriminate based on gender, race, ethnicity or geography. People with a family history of ADPKD and younger people who develop high blood pressure may be diagnosed with ADPKD.
In ADPKD, kidneys enlarge with age because they contain many cysts, or fluid-filled sacs. Over years, these cysts grow in size and in number and lead to kidney failure in about half of ADPKD patients. Medical evaluation consists of blood and urine tests, ultrasound or kidney MRI, and sometimes genetic testing.
At New York University (NYU) Langone Medical Center our medical experts are highly experienced in treating ADPKD and its complications, as well as providing dialysis and transplants to kidney failure patients. We also guide patients to important clinical trials. NYU researchers are at the cutting edge of investigative science in developing potential therapies for ADPKD.
What do the kidneys do?
What is Autosomal Dominant Polycystic Kidney Disease (ADPKD)?
What causes ADPKD?
How do you know if you have ADPKD?
What are the symptoms of ADPKD?
How is ADPKD treated?
How can NYU Medical Center help an ADPKD patient?
NYU nephrologists who are highly skilled in the diagnosis and management of ADPKD are located in the offices of the Faculty Group Practice.
[Click here for more information on PKD in Spanish and English.]
NYU Langone Medical Center
Faculty Practice Tower
530 First Avenue, Suite 9N
New York, NY 10016
Tel: (212) 263-5851
The kidneys are normally about the size of a fist and are located just below the rib cage near the back. They perform numerous essential functions, such as:
In this disease cysts develop inside the kidneys. Cysts are fluid-filled sacs. Theses cysts grow in size and number over years, impairing normal kidney functions. As the cysts grow, the kidneys enlarge in size. Over time, this causes kidney failure in about half of ADPKD patients.
This disease is caused by a mutation in a single gene. A gene carries a code for a protein, and polycystin protein becomes abnormal if the gene is mutated. Most mutations run in families, and occasionally a new mutation occurs in a person without a family history of ADPKD. This gene and its protein are important in controlling proper cell growth and development. When the gene is mutated, this growth process goes awry, and cells form abnormal cysts.
There are a few different scenarios where ADPKD may be suspected:
There are usually no symptoms early in the disease. Those people that do not progress to kidney failure may never feel any symptoms. Other people may have:
Currently, there is no established treatment to reverse or slow the progression of ADPKD, but testing of new therapies is underway.
Our nephrologists specialize in diagnosis and management of ADPKD, and guide to clinical trials that evaluate new therapies. Our researchers are working at the cutting edge of science to derive potential therapies for ADPKD and to quickly translate them into clinical trials.