Chronic kidney disease is a known accelerant of atherosclerosis. Indeed, cardiovascular disease is the leading cause of death in patients with kidney disease. Even after accounting for frequently comorbid conditions, such as diabetes and hypertension, renal disease emerges as an independent risk factor for cardiovascular disease. The specific mechanisms responsible have not yet been fully elucidated. This study aims to advance the understanding of kidney disease related atherosclerosis by examining the mechanisms by which renal disease may interfere with the regression of atherosclerosis. Atherosclerotic plaques are dynamic: the net result of progressive and regressive forces. Pilot data suggests that decreased renal function inhibits regression of atherosclerosis. Conventional therapy does not fully mitigate the excess cardiovascular risk afflicting the large and growing population of patients with kidney disease. Investigating novel pathomechanisms of renal disease, such as impaired atherosclerosis regression, is a desirable goal.
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